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The economic, social and legal consequence resulting from use. Moreover, they believe that the harmful consequences of use can be mitigated through controlled and safe use practices. These methods of mitigation include practices that ensure the purity of the drug, use in controlled environments with trusted individuals, and limiting the amount and frequency of use. Ultimately, the study finds that online discussions provide a rich exemplar of Beck’s theory of contested definitions of risk and harm.

Still best known as a party drug, ketamine’s reputation as a new type of antidepressant has grown steadily in recent years. It was first synthesised in 1962 by Calvin L Stevens, a chemist in Detroit who was trying to develop a more manageable alternative to PCP to use as an anaesthetic. By 1970 it had been approved by the FDA and was being given to American soldiers fighting in Vietnam, where it proved revolutionary as, unlike other anaesthetics, it barely affects the respiratory system.

That meant medics could operate on the battlefield without breathing machines. Still more remarkably, anecdotal reports began to emerge that even soldiers who’d had their limbs blown off were less likely to experience post-traumatic stress if they’d been given ketamine. By the 90s, studies of soldiers returning from the Gulf War showed that using ketamine greatly reduced the prevalence of PTSD, spurring curiosity about its potential for therapeutic use.

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